
Isla Grande Vacations from $967
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Your Isla Grande Vacation
With a Isla Grande vacation package, say goodbye to endless planning and hello to stress-free adventure. Every detail of your getaway has been taken care of before you go, so you can enjoy each moment discovering this lively city. If taking in the sights is a priority during your trip to Isla Grande, be sure to swing by famous attractions like Isla Mamey and Portobelo National Park. Whoever you're heading away with and whatever you want to spend, your dream Isla Grande vacation is just a few clicks away with Expedia.
The Latest Isla Grande vacation packages
Price found within the past 48 hours. Click for updated prices.



Casa Mallet by Wynwood House
Casco Viejo
Price was $2,135, price is now $1,375 per person
$1,375
per person
Jan 15 - Jan 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (30 reviews)
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect.
The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us.
I would stay here again in a heart beat.
It’s a must stay!
Reviewed on Sep 16, 2026

Casa La Costa By Wynwood House
Casco Viejo
Price was $1,965, price is now $1,309 per person
$1,309
per person
Feb 1 - Feb 8
found 19 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
7.8/10 Good! (34 reviews)
The bed was fine, but the closet and the floor were quite dirty. There was also an unpleasant smell in my room.
Reviewed on Jul 25, 2026

Central Hotel Panama Casco Viejo
Casco Viejo
Price was $2,133, price is now $1,432 per person
$1,432
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)
Excellent location. Breakfast buffet was good. Air conditioning excellent. Staff was excellent. Shower leaked badly. Mold on bathroom grout. Would stay there again.
Reviewed on Nov 12, 2026
What to do in Isla Grande

Private Catamaran Escape: Caribbean Beaches, Snorkeling & Lunch
$2,125
per traveler
Isla Grande Hotel Deals

Ordovician Beach Resort
Isla Grande Isla Grande Colon
$422 nightly
The price is $468 total per night from Nov 14 to Nov 15
$468 total
Nov 14 - Nov 15
Total with taxes and fees
10/10 Exceptional! (16 reviews)
"The best place in the world to have a relax and amazing vacation."
Reviewed on Nov 5, 2026

HOTEL ISLA GRANDE
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
$99 nightly
The price is $109 total per night from Nov 13 to Nov 14
$109 total
Nov 13 - Nov 14
Total with taxes and fees
4.4/10 (13 reviews)
"Rundown hotel. Not worth the price"
Reviewed on Aug 31, 2026

Hotel Cocotal
La Guaira Isla Grande Provincia de Colón
8.6/10 Excellent! (11 reviews)
"Ocean view! Peaceful and the staff was SUPER attentive and friendly."
Reviewed on Jun 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Isla Grande Vacation Packages
Isla Grande Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Max Temp Winter | 80ºF |
Max Temp Summer | 85ºF |
Top Sights | Blanca Beach, Portobelo National Park and Mirador Perú |
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- Visit Portobelo
- Real Aduana de Portobelo
- Visit Puerto Lindo
- Buenaventura Vacations
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- Visit Isla Grande
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- Fuerte San Fernando
- Blanca Beach
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- Portobelo National Park
- Fuerte San Jerónimo
- Nombre de Dios Vacations
- Visit Buenaventura
- Puerto Lindo Vacations
- Isla Mamey
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.



















